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NOVEL FLUORENE DERIVATIVE COMPOUND AND USE THEREOF
Author
HS Pagire, IK Lee, JH Jeon, SH Pagire, PK kim, CJ Oh, YH Jeon, KH Son and Jin Hee Ahn
Year
2024
Source
WO 2024071629
Discovery of a peripheral 5HT2A antagonist as a clinical candidate for Metabolic Dysfunction-Associated Steatohepatitis
Author
Haushabhau S. Pagire, Suvarna H Pagire, Byung-kwan Jeong, Won-il Choi, Chang Joo Oh, Chae Won Lim, Minhee Kim, Jihyeon Yoon, Seong Soon Kim, Myung Ae Bae, Jae-Han Jeon, Sungmin Song, Hee Jong Lee, Eun Young Lee, Peter Goughnour, Dooseop Kim, In-Kyu Lee, Rohit Loomba, Hail Kim*, Jin Hee Ahn*
Year
2024
Source
Nature Communications 2024, 15, 645
Design, synthesis, and biological evaluation of new 2,6,7-substituted purine derivatives as Toll-like receptor 7 agonists for intranasal vaccine adjuvants
Author
Morgan Kim, Kyungseob Noh, Pyeongkeun Kim, Jaeho Kim, Byeong Wook Choi, Ravi Singh, Junho Choi, Soo Bong Han, Seong Soon Kim, Eun-Young Lee, Myung Ae Bae, Daeho Shin, Meehyein Kim*, Jin Hee Ahn*
Year
2024
Source
J. Med. Chem. 2024, 67, 9389-9405
Discovery of Novel Arylpyridine Derivatives for Motile Ciliogenesis
Author
Gwi Bin Lee, Gopalakrishnan Chandrasekaran, Hee-Joong Kim, Pyeongkeun Kim,, Jihyeon Yoon, Byeong Wook Choi, So-Hyun Lee, Sang-Yong Lee, Dae-Seop Shin, Byung Hoi Lee, Myung Ae Bae, Peter Goughnour, Eun Young Choi, Seok-Yong Choi* and Jin Hee Ahn*
Year
2024
Source
Eur J Med Chem 2024, 277, 116764
PDK4-mediated metabolic reprogramming is a potential therapeutic target for neovascular age-related macular degeneration
Author
Juhee Kim, Yujin Jeon, Jinyoung Son, Haushabhau S. Pagire, Suvarna H. Pagire, Jin Hee Ahn, Akiyoshi Uemura, In-Kyu Lee, Sungmi Park* and Dong Ho Park*
Year
2024
Source
Cell Death & Disease 2024, 15, 582
Activation mechanism and novel binding sites of the BKCa channel activator CTIBD
Author
Narasaem Lee, Subin Kim1, Na Young Lee, Heeji Jo, Pyeonghwa Jeong, Haushabhau S Pagire, Suvarna H Pagire, Jin Hee Ahn, Mi Sun Jin, Chul-Seung Park*
Year
2024
Source
Life Science Alliance 2024, 7, e202402621
Preparation of pyrrolopyrimidine derivative for preventing or treating metabolic liver disease
Author
Bae, Myung Ae; Ahn, Jin Hee; Yang, Jung Yoon; Shin, Dae Seop; Hwang, Kyu Seok; Kim, Seong Soon; Lee, Byung Hoi; Ahn, Se Hwan; Kim, Dong Gun; Heo, Ye Rim
Year
2023
Source
WO 2023014049
Synthesis and biological evaluation of xanthine derivatives with phenacyl group as tryptophan hydroxylase 1 (TPH1) inhibitors for obesity and fatty liver disease
Author
Jihyeon Yoon, Won-Il Choi, Saravanan Parameswaran, Gwi Bin Lee, Byung Wook Choi, Pyungkeun Kim, Dae-Seop Shin, Ha Neul Jeong, Seung Mi Lee, Chang Ju Oh, Jae-Han Jeon, In-Kyu Lee, Myung Ae Bae*, Hail Kim*, Jin Hee Ahn*
Year
2023
Source
Bioorg. & Med. Chem. Lett. 2023, 94, 129461
Inhibition of PDK4 ameliorates renal ischemia-reperfusion injury by reducing succinate 3 accumulation during ischemia and preserving mitochondrial function during reperfusion
Author
Chang Joo Oh, Min-Ji Kim, Ji-Min Lee, Dong Hun Kim, Il-Young Kim, Sanghee Park, Yeongmin Kim, Kyung-Bok Lee, Sang-Hee Lee, Chae Won Lim, Myeongjin Kim, Jung-Yi Lee, Haushabhau S. Pagire, Suvarna H. Pagire, Myung Ae Bae, Dipanjan Chanda, Themis Thoudam, Ah Reum Khang, Robert A. Harris, Jin Hee Ahn*, Jae-Han Jeon*, In-Kyu Lee*
Year
2023
Source
Kidney International 2023, 104, 724-739
Inhibition of pyruvate dehydrogenase kinase 4 in CD4+ T cells ameliorates intestinal inflammation
Author
Hoyul Lee, Jae Han Jeon, Yu-Jeong Lee, Mi-Jin Kim, Woong Hee Kwon, Dipanjan Chanda, Themis Thoudam, Haushabhau S. Pagire, Suvarna H. Pagire, Jin Hee Ahn, Robert A. Harris, Eun Soo Kim, In-Kyu Lee*
Year
2023
Source
Cellular and Molecular Gastroenterology and Hepatology 2023, 15, 439-461
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